/* ─────────────────────────────────────────────
   Fiche médicament — interactions et restrictions (RCP)
   Vocabulaire Clinical Workstation : surfaces claires, accents teal,
   convention médicale verte → rouge pour les niveaux de contrainte.
   Les teintes de texte des badges sont foncées pour tenir le contraste
   WCAG AA (≥ 4,5:1) ; les bordures reprennent les tokens --stage-*.
───────────────────────────────────────────── */
.drug-sheet {
  --ix-ci-bg: #B91C1C;      /* rouge 700 : 6,5:1 avec du blanc */
  --ix-ad-bg: #C2410C;      /* orange 700 : 5,2:1 avec du blanc */
  --ix-pe-bg: var(--stage-3);
  --ix-ci-text: #B91C1C;
  --ix-ad-text: #C2410C;
  --ix-pe-text: #854D0E;
  --rx-list-1: #B91C1C;     /* cadre rouge des boîtes de liste I */
  --rx-list-2: #15803D;     /* cadre vert des boîtes de liste II */
  --drug-radius: 0;
}
[data-theme="dark"] .drug-sheet {
  --ix-ci-text: #FCA5A5;
  --ix-ad-text: #FDBA74;
  --ix-pe-text: #FDE047;
  --rx-list-1: #F87171;
  --rx-list-2: #4ADE80;
}

.drug-sheet { color: var(--ink); }
.drug-sheet :is(h1, h2, h3, h4) { color: var(--ink); }
.drug-sheet [id] { scroll-margin-top: calc(var(--stack-h, 3.5rem) + 1rem); }
.drug-sheet .sr-only { position: absolute; width: 1px; height: 1px; padding: 0; margin: -1px; overflow: hidden; clip: rect(0 0 0 0); white-space: nowrap; border: 0; }

/* En-tête */
.drug-hero { margin-bottom: 1.25rem; }
.drug-hero h1 { font-size: clamp(1.5rem, 3vw, 2.3rem); line-height: 1.2; letter-spacing: -.025em; font-weight: 600; margin: 0 0 .7rem; overflow-wrap: anywhere; }
.drug-hero__substances { display: flex; flex-wrap: wrap; gap: .35rem .9rem; list-style: none; padding: 0; margin: 0 0 .8rem; }
.atc-page .drug-hero__substances a { color: var(--teal-text); font-size: .86rem; font-weight: 500; text-decoration: none; letter-spacing: .01em; overflow-wrap: anywhere; }
.atc-page .drug-hero__substances a:hover { text-decoration: underline; text-underline-offset: 3px; }
.drug-hero__tags:not(:has(li)) { display: none; }
.drug-hero__tags { display: flex; flex-wrap: wrap; align-items: center; gap: .4rem; list-style: none; padding: 0; margin: 0 0 .9rem; }
.drug-chip { display: inline-flex; align-items: center; gap: .45rem; min-height: 28px; padding: .2rem .6rem; border: 1px solid var(--rule); border-radius: 0; background: var(--surface); color: var(--ink-soft); font-size: .72rem; line-height: 1.3; text-decoration: none; }
.atc-page a.drug-chip { color: var(--ink-soft); }
.atc-page a.drug-chip:hover { border-color: var(--teal); background: var(--teal-bg); color: var(--ink); }
.drug-chip > span { font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .66rem; color: var(--teal-text); }
.drug-chip--warn { border-color: var(--warn-border); background: var(--warn-bg); color: var(--warn-text); }
.drug-hero__meta { color: var(--ink-soft); font-size: .84rem; line-height: 1.6; margin: 0 0 1rem; overflow-wrap: anywhere; }
.drug-hero__actions { display: flex; flex-wrap: wrap; gap: .6rem; }
.drug-hero__actions .atc-button svg, .drug-button-secondary svg { flex: 0 0 auto; }
.atc-page .drug-button-secondary { display: inline-flex; align-items: center; gap: .5rem; padding: .8rem 1.1rem; border: 1px solid var(--rule); border-radius: 0; background: var(--surface); color: var(--ink); font-size: .85rem; font-weight: 500; text-decoration: none; }
.atc-page .drug-button-secondary:hover { border-color: var(--teal); background: var(--teal-bg); }

/* Documents officiels, en fin de fiche */
.drug-official { margin-top: 1.25rem; padding: 1.2rem; border: 1px solid var(--rule); border-left: 3px solid var(--teal); background: var(--surface); }
.drug-official p { margin: 0 0 .9rem; color: var(--ink-soft); font-size: .82rem; line-height: 1.6; }

/* Informations de sécurité en cours */
.drug-alerts { border: 1px solid var(--warn-border); border-left-width: 3px; border-radius: 0; background: var(--warn-bg); color: var(--warn-text); padding: .85rem 1rem; margin-bottom: 1.25rem; }
.drug-alerts__title { display: flex; align-items: center; gap: .5rem; font-weight: 600; font-size: .82rem; margin: 0 0 .5rem; }
.drug-alerts ul { list-style: none; padding: 0; margin: 0; display: grid; gap: .45rem; }
.drug-alerts li { display: flex; flex-wrap: wrap; gap: .2rem .7rem; font-size: .8rem; line-height: 1.5; }
.atc-page .drug-alerts a { color: inherit; font-weight: 500; text-underline-offset: 3px; }
.drug-alerts li > span { font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .66rem; opacity: .85; align-self: center; }
.atc-page .drug-alerts__more { display: inline-block; margin-top: .55rem; color: inherit; font-size: .76rem; }

/* Mise en page : contenu + sommaire collant */
.drug-layout { display: grid; gap: 1.25rem; align-items: start; }
.drug-main { min-width: 0; }
.drug-toc { order: -1; min-width: 0; }
.drug-toc__title { display: none; }
.drug-toc ol { display: flex; gap: .4rem; overflow-x: auto; list-style: none; padding: 0 0 .3rem; margin: 0; scrollbar-width: thin; }
.drug-toc li { flex: 0 0 auto; }
.drug-toc__sub, .drug-toc__rcp { display: none !important; }
.atc-page .drug-toc a { display: inline-flex; align-items: center; gap: .45rem; min-height: 36px; padding: .4rem .7rem; border: 1px solid var(--rule); border-radius: 0; background: var(--surface); color: var(--ink-soft); font-size: .76rem; text-decoration: none; white-space: nowrap; }
.atc-page .drug-toc a:hover { color: var(--ink); border-color: var(--teal); background: var(--teal-bg); }
.drug-toc svg { color: var(--teal-text); }
@media (min-width: 1024px) {
  .drug-layout { grid-template-columns: minmax(0, 1fr) 232px; gap: 1.75rem; }
  .drug-toc { order: 0; position: sticky; top: calc(var(--stack-h, 3.5rem) + 1rem); border: 1px solid var(--rule); border-top: 2px solid var(--teal); border-radius: 0; background: var(--surface); padding: 1rem .6rem .8rem; }
  .drug-toc__title { display: block; margin: 0 .5rem .6rem; font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .62rem; letter-spacing: .06em; text-transform: uppercase; color: var(--ink-faint); }
  .drug-toc ol { flex-direction: column; overflow: visible; gap: .1rem; padding: 0; }
  .atc-page .drug-toc a { display: flex; width: 100%; min-height: 34px; border: 0; border-radius: 0; background: transparent; padding: .4rem .5rem; white-space: normal; }
  .atc-page .drug-toc a:hover { background: var(--teal-bg); }
  .drug-toc__sub { display: block !important; }
  .atc-page .drug-toc__sub a { padding-left: 2.1rem; min-height: 28px; font-size: .72rem; color: var(--ink-faint); }
  .drug-toc__rcp { display: flex !important; margin: .7rem .5rem 0; padding-top: .7rem; border-top: 1px solid var(--rule); }
  .atc-page .drug-toc__rcp { gap: .4rem; font-size: .74rem; font-weight: 500; text-decoration: none; }
}

/* Synthèse (lignes « Liste des interactions » et « Restrictions ») */
.drug-summary { border: 1px solid var(--rule); border-radius: 0; background: var(--surface); overflow: hidden; }
.atc-page a.drug-summary__row { display: grid; grid-template-columns: 38px minmax(0, 1fr) 16px; grid-template-areas: "icon label chevron" "icon values chevron"; align-items: center; gap: .35rem .85rem; padding: .85rem 1rem; color: var(--ink); text-decoration: none; }
.drug-summary__row + .drug-summary__row { border-top: 1px solid var(--rule-soft); }
.atc-page a.drug-summary__row:hover { background: color-mix(in srgb, var(--teal-bg) 55%, var(--surface)); }
.drug-summary__icon { grid-area: icon; display: inline-flex; align-items: center; justify-content: center; width: 38px; height: 38px; border-radius: 0; background: var(--teal-bg); color: var(--teal-text); border: 1px solid color-mix(in srgb, var(--teal) 15%, var(--rule)); }
.drug-summary__label { grid-area: label; display: flex; flex-wrap: wrap; align-items: baseline; gap: .1rem .6rem; font-weight: 600; font-size: .9rem; }
.drug-summary__label small { font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-weight: 400; font-size: .62rem; color: var(--ink-faint); letter-spacing: .02em; }
.drug-summary__values { grid-area: values; display: flex; flex-wrap: wrap; align-items: center; gap: .35rem; }
.drug-summary__chevron { grid-area: chevron; color: var(--ink-faint); display: inline-flex; }
@media (min-width: 640px) {
  .atc-page a.drug-summary__row { grid-template-columns: 38px minmax(0, 1fr) auto 16px; grid-template-areas: "icon label values chevron"; }
  .drug-summary__values { justify-content: flex-end; }
}
.drug-tag { display: inline-flex; align-items: center; min-height: 26px; padding: .15rem .55rem; border-radius: 0; background: var(--surface-alt); border: 1px solid var(--rule); color: var(--ink-soft); font-size: .7rem; }

/* Badges de niveau de contrainte */
.ix-badge { display: inline-flex; align-items: center; justify-content: center; min-width: 28px; height: 26px; padding: 0 .45rem; border-radius: 0; font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .74rem; font-weight: 600; line-height: 1; border: 1px solid transparent; }
.ix-badge--ci { background: var(--ix-ci-bg); color: #fff; }
.ix-badge--ad { background: var(--ix-ad-bg); color: #fff; }
.ix-badge--pe { background: var(--ix-pe-bg); color: #0F172A; }
.ix-badge--apec { background: var(--warn-bg); color: var(--warn-text); border-color: var(--warn-border); }

/* Pictogrammes de restrictions */
.rx-pict { display: inline-flex; align-items: center; justify-content: center; width: 30px; height: 30px; border-radius: 0; border: 1px solid var(--rule); background: var(--surface-alt); color: var(--ink-faint); }
.rx-pict--ci { background: var(--ix-ci-bg); border-color: var(--ix-ci-bg); color: #fff; }
.rx-pict--warn { background: var(--ix-ad-bg); border-color: var(--ix-ad-bg); color: #fff; }
.rx-pict--info { background: var(--teal-bg); border-color: color-mix(in srgb, var(--teal) 40%, var(--rule)); color: var(--teal-text); }
.rx-pict--na { border-style: dashed; background: transparent; }
.rx-list { display: inline-flex; align-items: center; min-height: 26px; padding: .1rem .5rem; border: 2px solid currentColor; border-radius: 0; font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .68rem; font-weight: 600; letter-spacing: .04em; text-transform: uppercase; background: var(--surface); }
.rx-list--i { color: var(--rx-list-1); }
.rx-list--ii { color: var(--rx-list-2); }
.rx-list--stupefiant { color: var(--ink); }

/* Sections */
.drug-section { margin-top: 1.25rem; padding: 1.2rem; background: var(--surface); border: 1px solid var(--rule); border-radius: 0; min-width: 0; }
.drug-section__head { display: flex; align-items: flex-start; gap: .8rem; margin-bottom: 1.1rem; }
.drug-section__icon { flex: 0 0 auto; display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; border-radius: 0; background: var(--teal-bg); color: var(--teal-text); }
.drug-section h2 { font-size: 1.1rem; font-weight: 600; letter-spacing: -.01em; margin: .1rem 0 .25rem; }
.drug-section__source { margin: 0; font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .63rem; line-height: 1.6; color: var(--ink-faint); }
.drug-note { display: flex; align-items: flex-start; gap: .6rem; margin: .5rem 0; padding: .8rem .9rem; border-radius: 0; background: var(--surface-alt); border: 1px solid var(--rule-soft); color: var(--ink-soft); font-size: .82rem; line-height: 1.6; }
.drug-note > svg { flex: 0 0 auto; margin-top: .2rem; color: var(--teal-text); }
.drug-note--action { flex-wrap: wrap; }
.drug-note--action > span { flex: 1 1 260px; }
.atc-page .drug-note--action > a { display: inline-flex; align-items: center; gap: .35rem; font-weight: 500; font-size: .8rem; }
.drug-fineprint { color: var(--ink-faint); font-size: .72rem; line-height: 1.65; margin: .8rem 0 0; }
.drug-link-arrow { display: inline-flex; align-items: center; gap: .4rem; margin-top: .9rem; font-size: .8rem; font-weight: 500; text-decoration: none; }

/* Texte du RCP */
.rcp-text { color: var(--ink-soft); font-size: .84rem; line-height: 1.68; }
.rcp-text p { margin: .3rem 0; }
.rcp-text .rcp-h { color: var(--ink); font-weight: 600; margin-top: .7rem; }
.rcp-text > :first-child { margin-top: 0; }
.rcp-text .rcp-note { margin: .6rem 0 .2rem; }
.rcp-note { display: flex; align-items: flex-start; gap: .5rem; padding: .45rem .6rem; border-radius: 0; background: var(--surface-alt); color: var(--ink); font-weight: 500; }
.rcp-note .ix-badge { flex: 0 0 auto; height: 22px; min-width: 36px; font-size: .6rem; }
.rcp-list { margin: .3rem 0; padding-left: 1.15rem; }
.rcp-list li { margin: .2rem 0; }
.rcp-list li::marker { color: var(--teal); }
.rcp-table { overflow-x: auto; margin: .6rem 0; border: 1px solid var(--rule); border-radius: 0; }
.rcp-table table { border-collapse: collapse; width: 100%; min-width: 480px; font-size: .76rem; }
.rcp-table :is(th, td) { padding: .45rem .55rem; border-bottom: 1px solid var(--rule-soft); text-align: left; vertical-align: top; }
.rcp-table th { background: var(--surface-alt); color: var(--ink); font-weight: 600; }
.rcp-ref { display: inline-flex; align-items: center; padding: .05rem .35rem; border-radius: 0; border: 1px solid var(--rule); font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .6rem; font-weight: 500; color: var(--ink-faint); white-space: nowrap; }

/* Interactions : outils */
.ix-toolbar { display: flex; flex-direction: column; gap: .7rem; margin-bottom: .6rem; }
.ix-filters { display: flex; flex-wrap: wrap; gap: .4rem; }
@media (max-width: 639px) {
  /* Une seule ligne défilante, comme le sommaire de la fiche. */
  .ix-filters { flex-wrap: nowrap; overflow-x: auto; margin-inline: -1.2rem; padding: 0 1.2rem .3rem; scrollbar-width: thin; }
  .ix-filter { flex: 0 0 auto; }
}
.ix-filter { display: inline-flex; align-items: center; gap: .45rem; min-height: 36px; padding: .35rem .7rem; border: 1px solid var(--rule); border-radius: 0; background: var(--surface); color: var(--ink-soft); font: inherit; font-size: .75rem; cursor: pointer; }
.ix-filter > span { font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .68rem; color: var(--ink-faint); }
.ix-filter > i { width: 9px; height: 9px; border-radius: 50%; background: var(--rule); }
.ix-filter--ci > i { background: var(--stage-5); }
.ix-filter--ad > i { background: var(--stage-4); }
.ix-filter--pe > i { background: var(--stage-3); }
.ix-filter--apec > i { background: var(--warn-bg); box-shadow: inset 0 0 0 1.5px var(--warn-border); }
.ix-filter:hover:not(:disabled) { border-color: var(--teal); }
.ix-filter.is-active { border-color: var(--teal); background: var(--teal-bg); color: var(--ink); font-weight: 600; }
.ix-filter:disabled { opacity: .5; cursor: not-allowed; }
.ix-search { position: relative; display: flex; align-items: center; min-height: 42px; border: 1px solid var(--rule); border-radius: 0; background: var(--surface); padding: 0 .4rem 0 .75rem; }
.ix-search:focus-within { border-color: var(--teal); box-shadow: 0 0 0 3px color-mix(in srgb, var(--teal) 12%, transparent); }
.ix-search__icon { display: inline-flex; color: var(--ink-faint); }
.ix-search input { flex: 1; min-width: 0; border: 0; outline: 0; background: transparent; color: var(--ink); font: inherit; font-size: .88rem; padding: .55rem .6rem; }
.ix-search input::-webkit-search-cancel-button { appearance: none; }
.ix-search__clear { display: inline-flex; align-items: center; justify-content: center; width: 32px; height: 32px; border: 0; background: transparent; color: var(--ink-soft); cursor: pointer; border-radius: 0; }
.ix-status { margin: 0 0 .4rem; font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .66rem; color: var(--ink-faint); }
.ix-more { display: flex; align-items: center; justify-content: center; gap: .6rem; width: 100%; min-height: 44px; margin-top: .8rem; border: 1px dashed color-mix(in srgb, var(--teal) 45%, var(--rule)); border-radius: 0; background: var(--teal-bg); color: var(--teal-text); font: inherit; font-size: .8rem; font-weight: 600; cursor: pointer; }
.ix-more:hover { border-style: solid; }
.ix-more span { font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .68rem; font-weight: 500; }
.ix-empty { margin: .6rem 0; padding: .9rem; border: 1px dashed var(--rule); border-radius: 0; color: var(--ink-soft); font-size: .8rem; line-height: 1.6; }
.ix-search { width: 100%; max-width: 440px; }

/* Interactions : groupes et protagonistes */
.ix-part + .ix-part { margin-top: 1.4rem; }
.ix-part__title { margin: 1.2rem 0 0; padding: .45rem .7rem; border-radius: 0; background: var(--surface-alt); font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .68rem; font-weight: 600; letter-spacing: .04em; color: var(--ink-soft); }
.ix-group__empty { margin: .3rem 0 0; font-size: .76rem; color: var(--ink-faint); font-style: italic; }
.ix-intro { margin: .4rem 0 1rem; padding: .8rem .9rem; border-radius: 0; background: var(--surface-alt); }
.ix-group { margin-top: 1rem; border-left: 3px solid var(--rule); padding-left: .9rem; }
.ix-group--ci { border-left-color: var(--stage-5); }
.ix-group--ad { border-left-color: var(--stage-4); }
.ix-group--pe { border-left-color: var(--stage-3); }
.ix-group--apec { border-left-color: var(--warn-border); }
.ix-group__title { display: flex; align-items: center; gap: .55rem; margin: 0 0 .3rem; font-size: .92rem; font-weight: 600; }
.ix-group__count { margin-left: auto; font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .7rem; font-weight: 500; color: var(--ink-faint); }
.ix-entries { list-style: none; padding: 0; margin: 0; }
.ix-entry { padding: .7rem 0; }
.ix-entry + .ix-entry { border-top: 1px solid var(--rule-soft); }
.ix-entry__with { display: flex; gap: .35rem; margin: 0 0 .25rem; font-size: .88rem; font-weight: 600; line-height: 1.45; overflow-wrap: anywhere; }
.ix-entry__with > span { color: var(--teal-text); font-family: var(--font-mono, 'IBM Plex Mono', monospace); }
.ix-group--ci .ix-entry__with > span { color: var(--ix-ci-text); }
.ix-group--ad .ix-entry__with > span { color: var(--ix-ad-text); }
.ix-group--pe .ix-entry__with > span { color: var(--ix-pe-text); }
.ix-entry--plain { color: var(--ink-soft); font-size: .84rem; line-height: 1.68; }
.ix-entry--plain p { margin: 0; }

/* Repliables */
.drug-details { margin-top: 1rem; border: 1px solid var(--rule); border-radius: 0; background: var(--surface); }
.drug-details > summary { display: flex; align-items: center; gap: .6rem; min-height: 46px; padding: .6rem .9rem; cursor: pointer; list-style: none; font-size: .84rem; font-weight: 600; color: var(--ink); }
.drug-details > summary::-webkit-details-marker { display: none; }
.drug-details > summary > svg:last-child { margin-left: auto; color: var(--ink-faint); transition: transform .15s; flex: 0 0 auto; }
.drug-details[open] > summary > svg:last-child { transform: rotate(90deg); }
.drug-details[open] > summary { border-bottom: 1px solid var(--rule-soft); }
/* Contenu toujours décollé des bords du panneau ; blocs espacés régulièrement. */
.drug-details__body { display: flex; flex-direction: column; gap: .75rem; padding: .9rem; }
.drug-details__body > * { margin: 0; }
.ix-legend dl { display: grid; gap: .7rem; margin: 0; }
.ix-legend dl > div { display: grid; gap: .25rem; }
.ix-legend dt { display: flex; align-items: center; gap: .55rem; font-size: .8rem; font-weight: 600; }
.ix-legend dd { margin: 0; color: var(--ink-soft); font-size: .78rem; line-height: 1.6; }
.ix-legend .ix-badge { min-width: 42px; font-size: .62rem; }

/* Restrictions : tuiles */
.rx-tiles { display: grid; grid-template-columns: repeat(auto-fill, minmax(138px, 1fr)); gap: .55rem; list-style: none; padding: 0; margin: 0; }
.rx-tile { display: flex; flex-direction: column; gap: .3rem; height: 100%; padding: .75rem .8rem; border: 1px solid var(--rule); border-radius: 0; background: var(--surface-alt); color: var(--ink); text-decoration: none; }
.atc-page a.rx-tile { color: var(--ink); }
.atc-page a.rx-tile:hover { border-color: var(--teal); }
.rx-tile__icon { display: inline-flex; color: var(--ink-faint); margin-bottom: .1rem; }
.rx-tile__label { font-size: .8rem; font-weight: 600; line-height: 1.35; }
.rx-tile__state { font-size: .7rem; line-height: 1.4; color: var(--ink-soft); }
.rx-tile--ci { background: color-mix(in srgb, var(--stage-5) 9%, var(--surface)); border-color: color-mix(in srgb, var(--stage-5) 55%, var(--rule)); }
.rx-tile--ci .rx-tile__icon, .rx-tile--ci .rx-tile__state { color: var(--ix-ci-text); }
.rx-tile--ci .rx-tile__state { font-weight: 600; }
.rx-tile--warn { background: color-mix(in srgb, var(--stage-4) 9%, var(--surface)); border-color: color-mix(in srgb, var(--stage-4) 55%, var(--rule)); }
.rx-tile--warn .rx-tile__icon, .rx-tile--warn .rx-tile__state { color: var(--ix-ad-text); }
.rx-tile--warn .rx-tile__state { font-weight: 600; }
.rx-tile--info { background: var(--teal-bg); border-color: color-mix(in srgb, var(--teal) 35%, var(--rule)); }
.rx-tile--info .rx-tile__icon { color: var(--teal-text); }
.rx-tile--na { border-style: dashed; background: transparent; }
.rx-ref { font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .62rem; opacity: .85; white-space: nowrap; }
.rx-caveat { margin-top: .6rem; }

/* Restrictions : détails par situation */
.rx-detail__icon { display: inline-flex; color: var(--teal-text); }
.rx-detail--ci .rx-detail__icon { color: var(--ix-ci-text); }
.rx-detail__state { font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .62rem; font-weight: 500; color: var(--ink-faint); }
.rx-detail--ci .rx-detail__state { color: var(--ix-ci-text); }
.rx-detail--warn .rx-detail__icon, .rx-detail--warn .rx-detail__state { color: var(--ix-ad-text); }
.rx-part { min-width: 0; }
/* Deux passages de texte consécutifs : un filet ; les encadrés colorés sont séparés par l'espacement. */
.rx-part:not(.rx-part--ci):not(.rx-part--warn) + .rx-part:not(.rx-part--ci):not(.rx-part--warn) { padding-top: .75rem; border-top: 1px solid var(--rule-soft); }
.rx-part__title { display: flex; flex-wrap: wrap; align-items: center; gap: .5rem; margin: 0 0 .35rem; font-size: .78rem; font-weight: 600; color: var(--ink); }
.rx-part--ci { padding: .8rem .9rem; background: color-mix(in srgb, var(--stage-5) 7%, var(--surface)); border: 1px solid color-mix(in srgb, var(--stage-5) 30%, var(--rule)); border-left: 3px solid var(--stage-5); }
.rx-part--warn { padding: .8rem .9rem; background: color-mix(in srgb, var(--stage-4) 8%, var(--surface)); border: 1px solid color-mix(in srgb, var(--stage-4) 30%, var(--rule)); border-left: 3px solid var(--stage-4); }

/* Restrictions : prescription, délivrance, remboursement */
.rx-cards { display: grid; gap: .8rem; margin-top: 1rem; }
@media (min-width: 720px) { .rx-cards { grid-template-columns: 1fr 1fr; } }
.rx-card { padding: 1rem; border: 1px solid var(--rule); border-radius: 0; background: var(--surface); min-width: 0; }
.rx-card h3 { display: flex; align-items: center; gap: .5rem; margin: 0 0 .8rem; font-size: .88rem; font-weight: 600; }
.rx-card h3 svg { color: var(--teal-text); }
.rx-card__sub { margin: .9rem 0 .35rem; font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .62rem; letter-spacing: .05em; text-transform: uppercase; color: var(--ink-faint); }
.rx-listing { display: flex; flex-direction: column; align-items: flex-start; gap: .5rem; }
.rx-listing p { margin: 0; font-size: .8rem; line-height: 1.6; color: var(--ink-soft); }
.rx-empty { margin: 0; font-size: .8rem; line-height: 1.6; color: var(--ink-soft); }
.rx-conditions { margin: 0; padding-left: 1.1rem; font-size: .8rem; line-height: 1.55; color: var(--ink); }
.rx-conditions li { margin: .25rem 0; }
.rx-conditions li::marker { color: var(--teal); }
.rx-monitoring { display: flex; gap: .6rem; margin-top: .9rem; padding: .7rem .8rem; border-radius: 0; background: var(--surface-alt); font-size: .78rem; line-height: 1.6; color: var(--ink-soft); }
.rx-monitoring p { margin: 0; }
.rx-triangle { color: var(--ink); font-size: .9rem; line-height: 1.5; }
.rx-rates { display: flex; flex-wrap: wrap; align-items: center; gap: .4rem .6rem; margin: 0; font-size: .76rem; color: var(--ink-soft); }
.rx-rate { display: inline-flex; align-items: center; min-height: 24px; padding: .1rem .45rem; border-radius: 0; background: var(--teal-bg); color: var(--teal-text); font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .72rem; font-weight: 600; }
.rx-indications { margin: .3rem 0; font-size: .78rem; line-height: 1.6; color: var(--ink-soft); }
.rx-agrement { display: flex; align-items: center; gap: .45rem; margin: .8rem 0 0; font-size: .78rem; color: var(--ink-soft); }
.rx-dot { width: 8px; height: 8px; border-radius: 50%; background: var(--ink-faint); }
.rx-dot--yes { background: var(--stage-1); }
.rx-ci > summary .rcp-ref { margin-left: .2rem; }

/* Présentations */
.drug-packs { list-style: none; padding: 0; margin: 0; border: 1px solid var(--rule); border-radius: 0; overflow: hidden; }
.drug-pack { display: grid; gap: .5rem; padding: .8rem .9rem; }
.drug-pack + .drug-pack { border-top: 1px solid var(--rule-soft); }
.drug-pack__label { margin: 0 0 .25rem; font-size: .84rem; line-height: 1.5; color: var(--ink); overflow-wrap: anywhere; }
.drug-pack__meta { display: flex; flex-wrap: wrap; gap: .2rem .8rem; margin: 0; font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .62rem; color: var(--ink-faint); }
.drug-pack__price { display: flex; flex-wrap: wrap; align-items: baseline; gap: .3rem .6rem; font-size: .7rem; color: var(--ink-faint); }
.drug-pack__price strong { font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .92rem; color: var(--ink); }
@media (min-width: 720px) {
  .drug-pack { grid-template-columns: minmax(0, 1fr) 210px; align-items: center; }
  .drug-pack__price { flex-direction: column; align-items: flex-end; text-align: right; gap: .2rem; }
}

/* Même substance */
.drug-siblings + .drug-siblings { margin-top: 1.4rem; }
.drug-siblings__title { display: flex; flex-wrap: wrap; align-items: baseline; gap: .3rem .7rem; margin: 0 0 .6rem; font-size: .9rem; font-weight: 600; }
.drug-siblings__title span { font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .66rem; font-weight: 400; color: var(--ink-faint); }
.atc-page a.drug-pack__label { display: block; color: var(--ink); text-decoration: none; font-weight: 500; }
.atc-page a.drug-pack__label:hover { color: var(--teal-text); text-decoration: underline; text-underline-offset: 3px; }

/* Classification et données administratives */
.drug-atc-path { list-style: none; padding: 0; margin: 0; border: 1px solid var(--rule); border-radius: 0; overflow: hidden; }
.drug-atc-path li + li { border-top: 1px solid var(--rule-soft); }
.atc-page .drug-atc-path a { display: grid; grid-template-columns: 74px minmax(0, 1fr); gap: .6rem; align-items: baseline; padding: .6rem .85rem; color: var(--ink); text-decoration: none; font-size: .8rem; }
.atc-page .drug-atc-path a:hover { background: var(--teal-bg); }
.drug-atc-path li:last-child a { font-weight: 600; background: color-mix(in srgb, var(--teal-bg) 60%, var(--surface)); }
.drug-atc-path li:nth-child(2) a { padding-left: 1.35rem; }
.drug-atc-path li:nth-child(3) a { padding-left: 1.85rem; }
.drug-atc-path li:nth-child(4) a { padding-left: 2.35rem; }
.drug-atc-path li:nth-child(5) a { padding-left: 2.85rem; }
.drug-facts { display: grid; margin: 0; border: 1px solid var(--rule); border-radius: 0; overflow: hidden; }
.drug-facts > div { display: grid; gap: .15rem; padding: .6rem .85rem; }
.drug-facts > div + div { border-top: 1px solid var(--rule-soft); }
.drug-facts dt { font-size: .72rem; color: var(--ink-faint); }
.drug-facts dd { margin: 0; font-size: .82rem; color: var(--ink); overflow-wrap: anywhere; }
@media (min-width: 640px) { .drug-facts > div { grid-template-columns: 210px minmax(0, 1fr); align-items: baseline; } }
.drug-section .atc-table th small { display: block; font-weight: 400; font-size: .68rem; color: var(--ink-faint); }
.drug-safety-list { list-style: none; padding: 0; margin: 0; display: grid; gap: .1rem; }
.drug-safety-list li { display: flex; flex-direction: column; gap: .15rem; padding: .6rem 0; font-size: .82rem; line-height: 1.5; }
.drug-safety-list li + li { border-top: 1px solid var(--rule-soft); }
.drug-safety-list li > span { font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .64rem; color: var(--ink-faint); }

.drug-sheet :is(a, button, summary, input):focus-visible { outline: 2px solid var(--teal-text); outline-offset: 2px; }
@media (prefers-reduced-motion: reduce) { .drug-details > summary > svg:last-child { transition: none; } }

@media print {
  .drug-toc, .ix-toolbar, .drug-hero__actions, .ix-status { display: none !important; }
  .drug-details:not([open]) > :not(summary) { display: block; }
  .drug-section { break-inside: avoid-page; border-color: #999; }
}

/* Pages substances */
.substance-list__ix { flex-direction: row; flex-wrap: wrap; gap: .3rem; }
@media (min-width: 720px) { .substance-list__ix { flex-direction: row; justify-content: flex-end; align-items: center; } }
.substances-letters { display: flex; flex-wrap: wrap; gap: .3rem; margin-bottom: 1rem; }
.atc-page .substances-letters a { display: inline-flex; align-items: center; justify-content: center; min-width: 36px; min-height: 36px; border: 1px solid var(--rule); background: var(--surface); font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .8rem; text-decoration: none; }
.atc-page .substances-letters a:hover { border-color: var(--teal); background: var(--teal-bg); }
.substances-letter h2 { margin: 0 0 .8rem; font-family: var(--font-mono, 'IBM Plex Mono', monospace); color: var(--teal-text); }
.substances-letter ul { columns: 16rem; column-gap: 1.5rem; list-style: none; padding: 0; margin: 0; }
.substances-letter li { display: flex; justify-content: space-between; gap: .5rem; break-inside: avoid; padding: .25rem 0; border-bottom: 1px solid var(--rule-soft); font-size: .82rem; }
.atc-page .substances-letter a { color: var(--ink); text-decoration: none; }
.atc-page .substances-letter a:hover { color: var(--teal-text); text-decoration: underline; }
.substances-letter li span { font-family: var(--font-mono, 'IBM Plex Mono', monospace); font-size: .66rem; color: var(--ink-faint); }

/* Illustrations décoratives ; les badges conservent leurs couleurs de statut. */
.medicine-topic-icon { display: inline-block; flex: 0 0 auto; object-fit: contain; vertical-align: middle; }
.drug-section__icon .medicine-topic-icon { width: 28px; height: 28px; }
.drug-summary__icon .medicine-topic-icon { width: 28px; height: 28px; }
.drug-toc .medicine-topic-icon { width: 20px; height: 20px; }

.substance-drug { display: grid; grid-template-columns: 32px minmax(0, 1fr) auto; gap: .75rem; align-items: start; }
.substance-drug__icon { display: block; object-fit: contain; }
.drug-sibling { display: grid; grid-template-columns: 32px minmax(0, 1fr); align-items: start; gap: .75rem; }
@media (max-width: 600px) { .substance-drug { grid-template-columns: 32px minmax(0, 1fr); } .substance-drug .substance-list__ix { grid-column: 2; } }